The PICO/T acronym is broken down as follows:
P=Patient population of interest
I =Intervention of interest
C=Comparison of interest
O=Outcome of interest
T=Time it takes to demonstrate an outcome
Initially only four components were included. Later, Melnyk & Fineout-Overholt added a fifth, representing time (i.e., the time it takes for the intervention to achieve an outcome, or how long participants are observed).
The example below is adapted from a research published in Oncologist journal conducted by Dr. Pergolotti and other researchers.
P=Adults with cancer (cancer-related fatigue or cognitive function impairment)
I=Occupational therapy treatment
O=Improved health, well-being and functional capacity
Melnyk B. M. & Fineout-Overholt E. (2010). Evidence-based practice in nursing & healthcare: A guide to best practice (2nd ed.). Philadelphia, PA: Lippincott, Williams & Wilkins.
Pergolotti, M., Williams, G. R., Campbell, C., Munoz, L. A., & Muss, H. B. (2016). Occupational Therapy for Adults With Cancer: Why It Matters. Oncologist, 21(3), 314-319. doi:10.1634/theoncologist.2015-0335